Review Article| Volume 5, ISSUE 1, P9-16, May 2022

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Platelet-Rich Fibrin


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        • Alves R.
        • Grimalt R.
        A review of platelet-rich plasma: history, biology, mechanism of action, and classification.
        Skin Appendage Disord. 2018; 4: 18-24
        • Wong S.
        • Khetarpal S.
        Platelet-rich plasma for hair growth.
        Adv Cosmet Surg. 2019; 2: 151-159
        • Sundaram H.
        • Mehta R.C.
        • Norine J.A.
        • et al.
        Topically applied physiologically balanced growth factors: a new paradigm of skin rejuvenation.
        J Drugs Dermatol. 2009; 8: 4-13
        • Fabi S.
        • Sundaram H.
        The potential of topical and injectable growth factors and cytokines for skin rejuvenation.
        Facial Plast Surg. 2014; 30: 157-171
        • Semsarzadeh N.
        • Andrasik W.
        • Khetarpal S.
        Stem cells and exosomes in aesthetic medicine.
        Adv Cosmet Surg. 2021; 4: 59-70
        • Sclafani A.P.
        • McCormick S.A.
        Induction of dermal collagenesis, angiogenesis, and adipogenesis in human skin by injection of platelet-rich fibrin matrix.
        Arch Facial Plast Surg. 2012; 14: 132-136
        • Tsay R.C.
        • Vo J.
        • Burke A.
        • et al.
        Differential growth factor retention by platelet-rich plasma composites.
        J Oral Maxillofac Surg. 2005; 63: 521-528
        • Wang X.
        • Yang Y.
        • Zhang Y.
        • et al.
        Fluid platelet-rich fibrin stimulates greater dermal skin fibroblast cell migration, proliferation, and collagen synthesis when compared to platelet-rich plasma.
        J Cosmet Dermatol. 2019; 18: 2004-2010
        • Choukroun J.
        • Adda F.
        • Schoeffer C.
        • et al.
        PRF: an opportunity in perio-implantology.
        Implantodontie. 2000; 42: 55-62
        • Elghblawi E.
        Platelet-rich plasma, the ultimate secret for youthful skin elixir and hair growth triggering.
        J Cosmet Dermatol. 2018; 17: 423-430
        • Dohan D.M.
        • Choukroun J.
        • Diss A.
        • et al.
        Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101: 37-44
        • Dohan D.M.
        • Choukroun J.
        • Diss A.
        • et al.
        Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101: 45-50
        • Harmon K.
        • Hanson R.
        • Bowen J.
        • et al.
        Guidelines for the use of platelet rich plasma.
        The International Cellular Medical Society, Las Vegas, NV2011 (Available at:) (September 1, 2021)
        • Yu P.
        • Zhai Z.
        • Jin X.
        • et al.
        Clinical application of platelet-rich fibrin in plastic and reconstructive surgery: a systematic review.
        Aesthetic Plast Surg. 2018; 42: 511-519
        • Gentile R.D.
        Easy platelet-rich fibrin (injectable/topical) for post-resurfacing and microneedle therapy.
        Facial Plast Surg Clin North Am. 2020; 28: 127-134
        • Motosko C.C.
        • Khouri K.S.
        • Poudrier G.
        • et al.
        Evaluating platelet-rich therapy for facial aesthetics and alopecia: a critical review of the literature.
        Plast Reconstr Surg. 2018; 141: 1115-1123
        • Sclafani A.P.
        • Azzi J.
        Platelet preparations for use in facial rejuvenation and wound healing: a critical review of current literature.
        Aesthetic Plast Surg. 2015; 39: 495-505
        • Karimi K.
        • Rockwell H.
        The benefits of platelet-rich fibrin.
        Facial Plast Surg Clin North Am. 2019; 27: 331-340
        • Nacopoulos C.
        • Vesala A.M.
        Lower facial regeneration with a combination of platelet-rich fibrin liquid matrices based on the low speed centrifugation concept-Cleopatra technique.
        J Cosmet Dermatol. 2020; 19: 185-189
        • Shashank B.
        • Bhushan M.
        Injectable platelet-rich fibrin (PRF): the newest biomaterial and its use in various dermatological conditions in our practice: a case series.
        J Cosmet Dermatol. 2021; 20: 1421-1426
        • Sclafani A.P.
        Platelet-rich fibrin matrix for improvement of deep nasolabial folds.
        J Cosmet Dermatol. 2010; 9: 66-71
        • Sclafani A.P.
        Safety, efficacy, and utility of platelet-rich fibrin matrix in facial plastic surgery.
        Arch Facial Plast Surg. 2011; 13: 247-251
        • Hassan H.
        • Quinlan D.J.
        • Ghanem A.
        Injectable platelet-rich fibrin for facial rejuvenation: A prospective, single-center study.
        J Cosmet Dermatol. 2020; 19: 3213-3221
        • Sclafani A.P.
        Platelet-rich fibrin matrix (PRFM) for androgenetic alopecia.
        Facial Plast Surg. 2014; 30: 219-224
        • Li Z.J.
        • Choi H.-I.
        • Choi D.-K.
        • et al.
        Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth.
        Dermatol Surg. 2012; 38: 1040-1046
        • Schiavone G.
        • Paradisi A.
        • Ricci F.
        • et al.
        Injectable platelet-, leukocyte-, and fibrin-rich plasma (iL-PRF) in the management of androgenetic alopecia.
        Dermatol Surg. 2018; 44: 1183-1190
        • Arora R.
        • Shukla S.
        Injectable-platelet-rich fibrin-smart blood with stem cells for the treatment of alopecia: a report of three patients.
        Int J Trichology. 2019; 11: 128-131
        • Mahapatra S.
        • Kumar D.
        • Subramanian V.
        • et al.
        Study on the efficacy of platelet-rich fibrin matrix in hair follicular unit transplantation in androgenetic alopecia patients.
        J Clin Aesthet Dermatol. 2016; 9: 29-35
        • Xiong S.
        • Qiu L.
        • Su Y.
        • et al.
        Platelet-Rich Plasma and Platelet-Rich Fibrin Enhance the Outcomes of Fat Grafting: A Comparative Study.
        Plast Reconstr Surg. 2019; 143: 1201e-1212e
        • Keyhan S.O.
        • Hemmat S.
        • Badri A.A.
        • et al.
        Use of platelet-rich fibrin and platelet-rich plasma in combination with fat graft: which is more effective during facial lipostructure?.
        J Oral Maxillofac Surg. 2013; 71: 610-621
        • Liang Z.J.
        • Lu X.
        • Li D.Q.
        • et al.
        Precise intradermal injection of nanofat-derived stromal cells combined with platelet-rich fibrin improves the efficacy of facial skin rejuvenation.
        Cell Physiol Biochem. 2018; 47: 316-329